This weekend will see the beginning of six weeks of construction across Melbourne’s roads and public transport network.

The works will see major delays for drivers as well as public transport users.

Due to the CityLink Tulla Widening project, the Tullamarine Freeway will experience closures in both directions from 10pm Friday.

Parts of the inbound Monash Freeway will close on Saturday and Sunday evening as work on the Westgate Tunnel project begins.

The M80 Ring Road is also being upgraded. As a result, outbound lanes on the Calder Freeway will be affected on Friday and Saturday night.

On Sunday morning there will be major delays around the Domain Tunnel, which will be completely closed from 5.30am until midday to make way for Run for the Kids.

Outbound lanes on the Westgate Freeway will also be closed between Domain Tunnel and the Bolte Bridge and the bridge will also close northbound lanes leading towards the airport.

Speaking to the Age, Chris Miller from the VicRoads Traffic Management Unit said traffic issues should be resolved by midday Sunday.

Across public transport, two level crossings are being removed at Grange Roads and Lower Plenty, and Rosanna Station is being rebuilt, forcing the closure of the Hurstbridge Line. The works begin on Friday night, with major delays expected for Monday morning commuters.

The $140.2 million Hurstbridge Rail Line Upgrade should be completed by April 29. Around 100 bus replacements will run in the interim, but hour-long delays are expected.

At different points between March 30 and April 15 works will be undertaken to remove two level crossings at Clayton. Passengers on the Cranbourne/Pakenham line could also experience hour-long wait times.

The works are timed to coincide with the beginning of school holidays and launch of the Melbourne Metro Tunnel project.