Emergency services including the Melbourne Fire Brigade (MFB) received multiple calls about the blaze after 12am on Sunday after embers and smoke were seen coming out of the roof of one of the buildings on Gough Street near Punt Road.
Approximately 60 fire fighters were involved in putting out the fire, which was declared under control at 02.05am on Sunday.
No injuries were reported and no one was found inside the buildings. There have been fires at the site several times this year.
The Punt Road on–ramp to CityLink is currently closed as a result of the fire, as is Gough Street.
A Citylink spokesperson told Broadsheet that Victoria police informed the transport group the on-ramp could be closed for a couple of days. Victoria Police told Broadsheet the ramp will be closed for the foreseeable future, but wouldn’t commit to a time frame.
Citylink said only outbound traffic is currently being affected and has advised drivers who use the roads as part of their morning commute to allow for extra travel time on Monday.
In March, the iconic heritage-listed sign was earmarked for repair following approval of a major development of the site.
It is unknown if the sign and the silo it sits on have been affected by the fire.